Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
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メンバー紹介

助教：清水康平
Assistant Professor: Kouhei Shimizu
shimizu.kohei(at)med.osaka-cu.ac.jp

自己紹介

疾患発症の分子メカニズムに興味があります。いつか新しい現象の発見から創薬につながる仕事ができればと思っています。
学生時代はずっとバスケをやっていました。たまに行くスポーツ観戦や観劇、ライブ参戦が楽しみです。
よろしくお願いします。

略歴

愛媛県松山市出身
2013年9月 愛媛大学大学院理工学研究科博士課程修了（澤崎達也教授）
ハーバード大学医学部BIDMC病理学部門ポスドク、東北大学大学院歯学研究科助教を経て2019年10月より現職。

主な研究業績

  1. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H. Biochemical and Biophysical Research Communications, 524(2):477-483, 2020.
  2. The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. Uematsu A, Kido K, Takahashi H, Takahashi C, Yanagihara Y, Saeki N, Yoshida S, Maekawa M, Honda M, Kai T, Shimizu K, Higashiyama S, Imai Y, Tokunaga F, Sawasaki T. The Journal of biological chemistry, 294(38), 14135-14148, 2019.
  3. Physiological functions of FBW7 in cancer and metabolism. Shimizu K, Nihira NT, Inuzuka H, Wei W. Cellular signaling, 46, 15-22, 2018.
  4. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H. Molecular cell, 68(4), 645-658.e5, 2017.
  5. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Nature medicine, 23(9), 1063-1071, 2017.
  6. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. Nature cell biology, 19(3), 177-188, 2017.
  7. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W. Science signaling, 10(466), 2017.
  8. Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression. Nagashima K, Fukushima H, Shimizu K, Yamada A, Hidaka M, Hasumi H, Ikebe T, Fukumoto S, Okabe K, Inuzuka H. Oncotarget, 8(6), 9947-9960, 2017.
  9. The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. Science signaling, 10(460), 2017.
  10. The apoptotic initiator caspase-8: its functional ubiquity and genetic diversity during animal evolution. Sakamaki K, Shimizu K, Iwata H, Imai K, Satou Y, Funayama N, Nozaki M, Yajima M, Nishimura O, Higuchi M, Chiba K, Yoshimoto M, Kimura H, Gracey AY, Shimizu T, Tomii K, Gotoh O, Akasaka K, Sawasaki T, Miller DJ. Molecular biology and evolution, 31(12), 3282-3301, 2014.
  11. Pctaire1/Cdk16 promotes skeletal myogenesis by inducing myoblast migration and fusion. Shimizu K, Uematsu A, Imai Y, Sawasaki T. FEBS letters, 588(17), 3030-3037, 2014.
  12. Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. Shimizu K, Sawasaki T. FEBS letters, 587(14), 2219-2225, 2013.
  13. Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3. Shimizu K, Takahama S, Endo Y, Sawasaki T. PLoS One, 7(8), e42721, 2012.
  14. Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling. Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T. FEBS letters, 585(12), 1835-1840, 2011.
  15. Characterization of a caspase-3-substrate kinome using an N- and C-terminally tagged protein kinase library produced by a cell-free system. Tadokoro D, Takahama S, Shimizu K, Hayashi S, Endo Y, Sawasaki T. Cell death & disease, 1, e89, 2010.
  16. Biotinylated-sortase self-cleavage purification (BISOP) method for cell-free produced proteins. Matsunaga S, Matsuoka K, Shimizu K, Endo Y, Sawasaki T. BMC biotechnology, 10, 42, 2010.

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